BCL2, technical only
Use
BCL2 is a member of a family of proteins involved in apoptosis with wide tissue distribution. In 90% of follicular lymphomas, a translocation occurs which juxtaposes the BCL2 gene at 18q21 to an immunoglobulin gene. This t(14;18) translocation can deregulate gene expression and results in BCL2 overexpression, which can be detected via IHC.
Special Instructions
Not provided.
Limitations
The test is limited to the technical component of BCL2 IHC staining without pathologist interpretation. Specimens must be fixed in 10% neutral buffered formalin or B plus and cannot use other fixatives, which will result in rejection.
Methodology
Immunoassay (IHC)
Biomarkers
BCL2
Protein
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Storage Instructions
Store at 15°C to 25°C
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |