C MYC 8q24 Rearrangement, paraffin
Use
FISH testing on paraffin-embedded cells for detection of c-MYC (8q24) gene rearrangement. c-MYC is frequently rearranged in aggressive B-cell lymphomas, including Burkitt’s lymphoma. Often ordered as part of the FP BURKITT Panel test.
Special Instructions
Not provided.
Limitations
The test is limited by the fixation and embedding quality of the tissue sample. Specimens preserved in B+ fixative or decalcified are generally unsuitable for analysis. The assay requires a minimum of three unstained slides and may be impacted by insufficient tissue quantity or quality.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number Region
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
5 slides preferred (3 slides minimum)
Container
positively charged slides
Collection Instructions
FFPE Tissue Block or unstained FFPE tissue; cut sections at 3-5 μm thickness, mounted on positively charged slides.
Patient Preparation
Tissues should be fixed in 10% neutral buffered formalin.
Storage Instructions
Store at 15°C to 25°C
Causes for Rejection
Improper fixative; Tissue not fixed; Insufficient tissue; Specimen exposed to extreme temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Stable indefinitely |