CA 125, technical only
Use
Cancer antigen 125 (CA125) is a glycoprotein expressed on the surface of epithelial ovarian neoplasms and various other tissues, including the endometrium, fallopian tubes, pleura, peritoneum, and pericardium. It is used as a tumor marker in ovarian cancer, aiding in diagnosis and monitoring of treatment response.
Special Instructions
Not provided.
Limitations
Samples must be tested within 3 months after placing in ethanol. Positive results should be interpreted with caution due to the potential for false positives from various other tissues. CA 125 levels can be affected by several factors, limiting its use as a standalone diagnostic tool.
Methodology
Immunoassay (IHC)
Biomarkers
CA125
Protein
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Fresh Tissues: Fixative should be at a 20:1 fixative to tissue ratio, 10% neutral buffered formalin (NBF) for 6-72 hours (48-72 hours PREFERRED).
Storage Instructions
Store at 15°C to 25°C. Use a refrigerated (NOT FROZEN) gel pack in the shipment to protect from extreme temperatures. Specimens may be transferred to 70% alcohol for transportation purposes after fixation.
Causes for Rejection
Specimens must be fixed in 10% NBF or B plus. All other fixatives will be rejected.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinite |
| Refrigerated | Indefinite |
| Frozen | Indefinite |