FIP1L1/PDGFRA 4q12 Rearrangement
Use
The FISH test on hematologic specimens is used for the detection of FIP1L1/CHIC2/PDGFRA (4q12) deletion and gene fusion. This involves a microdeletion involving the CHIC2 locus leading to the fusion of the FIP1L1 and PDGFRA genes. This abnormality is most frequently observed in eosinophilia and myeloproliferative neoplasms and is often ordered as part of the F EOSINOPHILA Panel.
Special Instructions
Not provided.
Limitations
The test is subject to predefined turnaround times that are designated for clinical use but may change based on biopharma protocol requirements. It detects deletions and fusions involving the specified genes but may not detect other abnormalities beyond the targeted region.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
FIP1L1, PDGFRA
GeneUnknown CNV
Copy Number Region
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells; Improper fixative.