IRF4 6p25 Rearrangement
Use
FISH test on hematologic specimens for detection of IRF4 (6p25) gene rearrangement. IRF4 rearrangements are most frequently observed in lymphoid neoplasms, including diffuse large B-cell lymphoma, classic Hodgkin lymphoma, follicular center cell lymphoma, and marginal zone B-cell lymphoma.
Special Instructions
All attempts will be made to process and report samples received > 72 hours post-collection. Bone marrow is the sample of choice in most heme malignancies.
Limitations
Stated turn-around-times (TATs) are for clinical use only and subject to change based on biopharma protocol requirements. Final TATs will be specified in the biopharma study contract. Clotted specimens, specimens exposed to extreme temperature, anticoagulants toxic to cells, or an insufficient number of cells are grounds for specimen rejection.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |