Myeloproliferative Disorders (MPD) Panel
Use
The MPD panel is a FISH test conducted on hematologic specimens to identify the most common genetic abnormalities observed in myeloproliferative disorders. This panel includes tests for trisomy 8, BCR::ABL1 gene fusion, 13q deletion, and 20q deletion, which are significant markers in the diagnosis and monitoring of myeloproliferative disorders.
Special Instructions
All attempts will be made to process and report samples received more than 72 hours post-collection, though bone marrow is the preferred sample type in most hematological malignancies.
Limitations
The accuracy of the test is dependent on specimen quality, timely processing, and the use of appropriate specimen types. Clotted specimens, those exposed to extreme temperatures, or specimens with an anticoagulant that is toxic to cells may be rejected. Analytical sensitivity may be affected by the presence of interfering substances or inadequate specimen volume.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
Store at 2°C to 25°C
Causes for Rejection
Clotted specimen; Specimens exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |