PML::RARA; t(15;17)
Use
FISH test on hematologic specimens for detection of PML::RARA gene translocation. PML::RARA translocation occurs in approximately 97% of patients with acute promyelocytic leukemia. This test is crucial in identifying cases where the PML::RARA fusion protein is present, which is commonly associated with acute promyelocytic leukemia, aiding in diagnosis and treatment decision-making.
Special Instructions
This is run as a STAT test. Please provide the ordering physician's or appropriate contact phone number to receive STAT results. All attempts will be made to process and report samples received more than 72 hours post-collection.
Limitations
The test is limited to the detection of the PML::RARA translocation and cannot detect other genetic abnormalities or mutations that may be present in the sample. Clotted specimens or specimens exposed to extreme temperatures may be rejected, potentially delaying diagnosis.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
Store at 2°C to 25°C
Causes for Rejection
Clotted specimen; Specimen exposed to extreme temperature; Anticoagulant toxic to cells; Insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |