PRDM16 1p36 Rearrangement
Use
The FISH test detects PRDM16 (1p36.32) gene rearrangement, which is a rare but recurrent finding in acute myeloid leukemia and myelodysplastic syndrome. This testing helps in diagnosing and managing these hematologic conditions, providing vital information for clinical treatment strategies.
Special Instructions
Not provided.
Limitations
The test results may be influenced by the quality and handling of the specimen. Specimens clotted, exposed to extreme temperatures, or containing toxic anticoagulants may be rejected. Additionally, an insufficient number of cells may lead to rejection. The test is categorized as RUO, indicating research use only and not intended for diagnostic procedures.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
PRDM16
Gene
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
Not provided
Container
EDTA preferred (NaHep accepted)
Storage Instructions
2°C to 25°C
Causes for Rejection
Clotted specimen; extreme temperature exposure; anticoagulant toxic to cells; insufficient number of cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |