ALK-1, (For heme cases)
Also known as: ALK1 for lymphoma
Use
ALK‑1 is a membrane‑spanning tyrosine kinase receptor and member of the insulin receptor family. Overexpression of ALK‑1 may result from translocations, mutations, and amplifications. Tumors with ALK‑1 translocations are sensitive to ALK‑1 inhibitors, making this assay useful for identifying a subgroup of anaplastic large‑cell lymphoma (ALCL) that are ALK‑positive.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
ALK1
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Paraffin block preferred; if submitting slides, use positively‑charged slides fixed in 10% NBF
Collection Instructions
Submit H&E slide (required) plus 2–3 unstained slides cut at 4–5 microns; block and slide identifiers must match specimen ID on requisition; do not use zinc fixatives
Storage Instructions
Slides can be packed at room temperature; use cold pack for transport but not in direct contact with specimen