ALL Adult FISH Panel
Also known as: Acute lymphoblastic leukemia
Use
The ALL Adult FISH Panel is used to detect recurrent chromosome abnormalities in adults with B-cell acute lymphoblastic leukemia (B-ALL) and B lymphoblastic lymphoma (LBL). Identifying specific abnormalities helps predict disease aggressiveness and response to therapy, guiding both risk stratification and treatment decisions. This panel includes key targets relevant to adult disease biology, including the Philadelphia chromosome (BCR-ABL1) and other translocations and copy number changes linked to prognosis and therapy selection. A positive result for BCR-ABL1, for example, indicates Philadelphia-positive ALL, which can be treated with tyrosine kinase inhibitors (TKIs) (Fielding et al., 2014; Jabbour et al., 2015). Similarly, detecting MYC or MLL rearrangements can signal more aggressive disease and the need for alternative treatment approaches (Arber et al., 2017). Trisomies and tetrasomies of chromosomes 4, 6, 10, and 17 can provide additional prognostic information and influence treatment intensity (Moorman et al., 2007).
Special Instructions
Not provided.
Limitations
This panel is designed specifically for adults and excludes probes for ETV6/RUNX1 t(12;21), which are more common in pediatric ALL (Pui et al., 2011). The insights provided by this panel support both initial diagnosis and ongoing management, helping oncologists tailor therapy to each patient’s genetic profile.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1-2 mL
Minimum Volume
Not provided
Container
sodium heparin tube. EDTA tube is acceptable
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze.