Use

The ALL Adult FISH Panel is used to detect recurrent chromosome abnormalities in adults with B-cell acute lymphoblastic leukemia (B-ALL) and B lymphoblastic lymphoma (LBL). Identifying specific abnormalities helps predict disease aggressiveness and response to therapy, guiding both risk stratification and treatment decisions. This panel includes key targets relevant to adult disease biology, including the Philadelphia chromosome (BCR-ABL1) and other translocations and copy number changes linked to prognosis and therapy selection. A positive result for BCR-ABL1, for example, indicates Philadelphia-positive ALL, which can be treated with tyrosine kinase inhibitors (TKIs) (Fielding et al., 2014; Jabbour et al., 2015). Similarly, detecting MYC or MLL rearrangements can signal more aggressive disease and the need for alternative treatment approaches (Arber et al., 2017). Trisomies and tetrasomies of chromosomes 4, 6, 10, and 17 can provide additional prognostic information and influence treatment intensity (Moorman et al., 2007).