ALL Pediatric FISH Panel
Also known as: Acute lymphoblastic leukemia
Use
The ALL Pediatric FISH Panel is used to detect recurrent chromosome abnormalities in pediatric patients with B-cell acute lymphoblastic leukemia (B-ALL) and B lymphoblastic lymphoma (LBL). Identifying specific genetic abnormalities helps predict disease aggressiveness, prognosis, and response to therapy, guiding both risk stratification and treatment decisions. This panel includes key probes relevant to pediatric disease biology, such as ETV6/RUNX1 t(12;21), a marker of favorable prognosis, and BCR/ABL1 t(9;22), a marker of Philadelphia chromosome-positive ALL.
Special Instructions
Test Customization: Probes may be ordered separately, except that Centromeres 4 and 17 are paired, as are Centromeres 6 and 10. CDKN2A (p16) deletion testing is available to be ordered separately. STAT Processing (upon request): Available for BCR/ABL1/ASS1 t(9;22).
Limitations
This panel is designed specifically for pediatric patients. Results interpretation should consider the entire clinical picture and not rely solely on the FISH results. The accuracy of the detection depends on probe efficiency, specimen quality, and other factors.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1-2 mL
Minimum Volume
Not provided
Container
sodium heparin tube. EDTA tube is acceptable.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For fresh samples: refrigerate before shipping and ship same day as drawn whenever possible. Do not freeze.