BCL2 (18q21)
Also known as: B-cell lymphoma
Use
This BCL2 break‑apart probe enables detection of BCL2 rearrangements at 18q21 irrespective of the partner gene. Detection of BCL2 rearrangement aids in diagnosis and classification of follicular lymphoma (FL), diffuse large B‑cell lymphoma (DLBCL), and other aggressive B‑cell lymphomas in conjunction with clinical, morphologic, and flow cytometric data. The most frequent rearrangement partner is IgH (14q32). Rarely, variant translocations involve the light chain genes Ig lambda (22q11) or Ig kappa (2p12), AFF3 (2q11), or the mu switch region. BCL2 functions in anti‑apoptosis and its overexpression is implicated in oncogenesis.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
BCL2
Gene
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1‑2 mL
Minimum Volume
Not provided
Container
sodium heparin tube (EDTA acceptable)
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | Refrigerate before shipping |
| Frozen | Do not freeze |