CD21
Use
CD21 (CR2, C3d receptor and EBV receptor) is expressed strongly on mature B-cells, follicular dendritic cells (FDC) and weakly on immature thymocytes and T-lymphocytes. It appears after the pre-B-stage, maintains during peripheral B-cell development, and is lost upon terminal differentiation into plasma cells. Immunohistological analysis of FDC in paraffin sections of Non-Hodgkin lymphoma (NHL) with this antibody demonstrates a nodular and usually dense and sharply defined FDC meshwork in follicular lymphomas and a loose, ill-defined FDC of varying size in some diffuse lymphoma types.
Special Instructions
A formalin-fixed, paraffin-embedded (FFPE) tissue block is the preferred specimen type or one unbaked, unstained slide for H&E staining is required, with two to three positively charged unstained slides for each test/antibody ordered.
Limitations
Precursor B-cell lymphoma (lymphoblastic lymphomas), Burkitt lymphomas, plasmacytomas, and hairy cell leukemias consistently lack CD21 expression.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Use cold pack for transport, ensuring it is not in direct contact with specimen. NYS clients please provide date and time of collection.