CD23 Immunohistochemistry (IHC)
Use
CD23 is identical to the low affinity IgE receptor found on B‑cells and is expressed on a subpopulation of peripheral blood cells, B‑lymphocytes, and EBV‑transformed B‑lymphoblastoid cell lines. It is most useful in distinguishing B‑cell chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) from other entities and may remain present in CLL/SLL that has undergone large cell transformation.
Special Instructions
Level of Service: Tech Only. Last Updated: January 28, 2026.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) plus two to three positively charged unstained slides, all cut at 4‑5 microns. Block and slide identifiers should match exact specimen ID.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen. For NYS clients, provide date and time of Collection.