CD3
Use
CD3 antigen is a marker of T‑cell lineage, first detectable in early thymocytes (cytoplasmic expression) and later on the membrane. It is the most specific T‑cell antibody, expressed in normal thymocytes, peripheral T‑cells, NK cells, and Purkinje cells of the cerebellum. In pathological contexts, CD3 immunohistochemistry (IHC) stains most T‑cell lymphomas, with only rare B‑cell lymphomas showing positivity.
Special Instructions
Tech Only service. Specimen requirements: Formalin‑fixed, paraffin‑embedded (FFPE) tissue block preferred, or one unbaked, unstained slide for H&E staining (required) plus two to three (2‑3) positively charged unstained slides (4‑5 microns) per test/antibody. Slide and block identifiers must match requisition. Storage/transport: Use cold pack not in direct contact; New York State clients must provide date and time of collection.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded tissue block preferred; or one unbaked, unstained slide for H&E and two to three positively charged unstained slides (4‑5 microns) per test.
Storage Instructions
Use cold pack for transport, ensure cold pack not in direct contact with specimen.
Causes for Rejection
Identifiers on block and slides must match specimen ID as noted on requisition.