CD57
Use
CD57 is expressed on subpopulations of peripheral blood mononuclear cells, including natural killer (NK)‑active cells and subsets of T‑cells. Hematopoietic malignancies that are CD57‑positive include a minority of T‑lymphoblastic leukemias, approximately three quarters of indolent T‑cell large granular lymphocytic leukemias, and a small portion of NK‑cell lymphomas. CD57 immunostaining is also useful to highlight small lymphoid cells in nodular lymphocyte‑predominant Hodgkin lymphoma.
Special Instructions
Level of Service: Technical Only. Block and slide identifiers must be clearly written and match the specimen ID and labeling on the requisition. For New York State clients, date and time of collection must be provided. Use cold pack for transport, ensuring it does not contact the specimen directly.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block or one unbaked, unstained H&E slide plus 2–3 positively charged unstained slides cut at 4–5 microns
Collection Instructions
Submit FFPE tissue block preferred; or one unbaked, unstained slide for H&E plus two to three positively charged unstained slides (4‑5 µm) for each test/antibody ordered; block and slide IDs must match requisition.
Storage Instructions
Use cold pack for transport; cold pack must not be in direct contact with specimen.