E‑Cadherin
Use
E‑Cadherin is an adhesion protein expressed in epithelial lineage cells. It is positive in glandular epithelium and adenocarcinomas of lung, gastrointestinal tract, and ovary, and some thyroid carcinomas. In breast carcinomas, E‑Cadherin distinguishes ductal versus lobular subtypes—lobular carcinomas show complete or near complete loss of membrane staining, whereas ductal carcinomas show uniform membrane expression. Thus, immunohistochemical detection of E‑Cadherin is a useful diagnostic tool for differentiating ductal and lobular carcinomas of the breast.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
E-Cadherin
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred, or one unbaked unstained slide for H&E (required) plus two to three positively charged unstained slides (4‑5 microns) for each test/antibody ordered. Block and slide identifiers must match requisition.
Storage Instructions
Use cold pack for transport, ensure cold pack not in direct contact with specimen. NYS clients: provide date and time of collection.