ICOS
Also known as: CD278
Use
ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T-cell activity and immune responses. This biomarker is primarily expressed on activated CD4+ and CD8+ T-cells and is crucial in diagnosing T-cell lymphomas of follicular helper T-cell origin. It is particularly useful when combined with additional markers for follicular helper T-cells.
Special Instructions
Block and slide identifiers should be clearly written and match exactly with the specimen ID and labeling on the requisition. Use cold pack for transport, ensuring it does not directly contact the specimen. NYS clients should provide the date and time of collection.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
One (1) unbaked, unstained slide for H&E staining (required) and two to three (2-3) positively charged unstained slides (all cut at 4-5 microns) for each test/antibody ordered.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.