MPN FISH Panel
Also known as: Myeloprofilerative neoplasms
Use
The MPN FISH panel is indicated in the diagnosis of myeloproliferative neoplasms with eosinophilia and as a guide to therapeutic selection. Patients with BCR‑ABL, PDGFRA or PDGFRB rearrangements are responsive to tyrosine kinase inhibitors. There currently is no established TKI therapy for diseases with FGFR1 rearrangement, but some promising new therapies have been reported. If these FISH studies are negative, that does not exclude a myeloproliferative neoplasm and molecular studies for JAK2 and/or MPL mutations should also be considered in the work‑up of a possible myeloproliferative neoplasm.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1-2 mL in sodium heparin tube
Minimum Volume
Not provided
Container
sodium heparin tube (EDTA acceptable)
Storage Instructions
Refrigerate before shipping; use cold pack not in direct contact; do not freeze