MUM1
Use
The MUM1 antibody is specific for the MUM1/IRF4 protein that is overexpressed in late plasma‑cell‑directed stages of B‑cell differentiation. It serves as a powerful tool for understanding the histogenesis of B‑cell lymphomas and is an excellent marker for Hodgkin and Reed‑Sternberg cells of classical Hodgkin lymphoma when used in combination with CD30. Moreover, MUM1 expression has prognostic value, being associated with poor prognosis in patients with diffuse large B‑cell lymphoma (DLBCL).
Special Instructions
Tech Only level of service. For New York State clients, date and time of collection must be provided. Use cold pack for transport, ensuring it is not in direct contact with specimen.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Formalin‑fixed, paraffin‑embedded (FFPE) tissue block preferred; alternatively one unbaked unstained slide for H&E staining (required) plus two to three positively charged unstained slides cut at 4‑5 microns. Block and slide identifiers must match the requisition.
Storage Instructions
Use cold pack during transport; cold pack should not be in direct contact with the specimen.