Use

Follicular lymphoma (FL) is among the most common non-Hodgkin lymphomas worldwide. FL is a fairly heterogeneous disease, with many patients achieving long-term remission and others who will have a remarkably poor outcome. Approximately 90% of FL cases harbor translocations involving BCL2, and the majority of these FL patients will also have one or more additional recurrent gene mutations. Variant follicular lymphomas such as pediatric-type FL, diffuse FL, and primary cutaneous follicle center lymphoma, have been characterized by the absence of BCL2, BCL6, and IRF4 gene rearrangements. Recent NGS studies have identified frequent/recurrent gene mutations and rearrangements in follicular lymphoma variants; for example, 70% of pediatric-type FL will have mutations in TNFRSF14 and/or MAP2K1, compared to 9% of BCL2-negative FL in adults. Genomic profiling in follicular lymphoma will not only provide diagnostic value, but may also suggest prognostic and therapeutic relevance.