NTRK NGS Fusion Panel
Also known as: NTRK NGS Fusion Profile
Use
The NTRK NGS Fusion Panel is an RNA‑based next‑generation sequencing assay designed to detect translocations and fusions involving the Neurotrophic Tropomyosin‑Related Kinase genes NTRK1, NTRK2, and NTRK3 with both known and novel fusion partners, as well as selected point mutations in specific exons of these genes. It is intended to guide therapy selection based on FDA‑approved TRK inhibitors such as ROZLYTREK® (entrectinib) and VITRAKVI® (larotrectinib).
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
NGS (Targeted)
Biomarkers
NTRK1, NTRK2, NTRK3
GeneUnknown fusion
Fusion
Result Turnaround Time
21 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Paraffin block is preferred. Alternatively, send 1 H&E slide plus 5‑10 unstained slides cut ≥5 microns. Use positively‑charged slides and 10% NBF fixative. Do not use zinc fixatives. Use cold pack for transport but not in direct contact with specimen. NYS clients please provide date and time of Collection.