NUP98 Rearrangement (11p15)
Use
Fusions of the nucleoporin 98 (NUP98) gene with more than 30 partner genes are noted in a variety of hematologic malignancies including AML, MDS, and T-ALL. Recurring NUP98 fusions, such as NUP98‑NSD1, NUP98‑JARID1A, and NUP98‑HOXA9, have been reported in pediatric and adult cytogenetically normal AML (CN-AML) and some have been associated with poor prognosis. Detection of NUP98 rearrangement may be useful to further classify prognostic risk in AML and guide therapy selection. Screening for NUP98 rearrangement in pediatric AML patients at the time of diagnosis has been suggested. This NUP98 break-apart FISH test is designed to detect NUP98 rearrangements with potentially any known or novel translocation partner.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
No genes
Gene
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1‑2 mL in sodium heparin tube
Minimum Volume
Not provided
Container
sodium heparin tube (EDTA tube acceptable)
Storage Instructions
Refrigerate, ship same day, do not freeze; cold pack not in direct contact