PDGFRa (4q12) FISH
Use
The PDGFRa FISH test is used to detect rearrangements in the PDGFRA gene, located at 4q12. This is relevant for the diagnosis of certain hematologic malignancies, such as chronic eosinophilic leukemia and myeloproliferative neoplasms (MPN). The presence of PDGFRa rearrangements may have prognostic implications and can guide treatment decisions.
Special Instructions
Ensure specimens do not contain biopsy needles, blades, or foreign objects as these can compromise specimen viability and safety. For NYS clients, provide date and time of collection.
Limitations
The FISH methodology may not detect all types of genetic alterations, including small deletions or point mutations in PDGFRA. Additionally, low-level mosaicism might not be detected due to limitations in the resolution of the technique. Results should be interpreted in the context of other laboratory and clinical findings.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1-2mL
Minimum Volume
Not provided
Container
Sodium Heparin Tube. EDTA tube is acceptable
Storage Instructions
Use cold pack for transport, ensuring it is not in direct contact with the specimen.
Causes for Rejection
Include biopsy needles, blades, and other foreign objects