Plasma Cell Myeloma IgH Complex FISH Panel
Also known as: Multiple Myeloma (MM) IgH Complex FISH Panel
Use
The panel is performed when IgH is rearranged. This panel is used to identify the IgH partner gene in myeloma, which has prognostic impact. IgH rearrangements are found in 55-70% of myelomas. Together t(4;14), t(11;14), t(14;16) and t(14;20) are found in approximately 35% of myelomas and in 90% of myelomas when there is an IgH gene rearrangement present.
Special Instructions
Probes for may be ordered separately. Plasma cell enrichment will be performed on bone marrow samples unless otherwise directed by the client. Plasma cell enrichment was not validated using peripheral blood; therefore, it is not recommended as a screening specimen unless increased plasma cells are seen on blood smear.
Limitations
Specimens should be received in our laboratory within 72 hours of collection. The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. Correct CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payor being billed.
New York Approved
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
1-2 mL
Minimum Volume
Not provided
Container
sodium heparin tube
Collection Instructions
EDTA tube is acceptable.
Storage Instructions
Refrigerate specimen. Do not freeze. Use cold pack for transport, making sure cold pack is not in direct contact with specimen. Specimens should be received in our laboratory within 72 hours of collection.