PTEN Immunohistochemistry (IHC)
Use
Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene mutated in a wide range of cancers. It regulates cell proliferation, apoptosis, and migration. Reduced expression is observed in malignancies such as breast, prostate, and endometrial cancer, and in Cowden syndrome tumors. Loss of PTEN expression in breast and prostate cancer correlates with advanced disease stage. Studies suggest PTEN expression may predict response to Herceptin in HER2-positive breast cancer.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
PTEN
Protein
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Preferred: formalin‑fixed, paraffin‑embedded (FFPE) tissue block or one unbaked, unstained H&E slide (required) plus two to three positively charged unstained slides (4‑5 microns). Identifiers must match requisition.
Storage Instructions
Use cold pack for transport; cold pack should not contact specimen. NYS clients: include date and time of collection.