Use

This RARA break-apart probe is useful for detecting variant RARA translocations with partners other than PML such as t(5;17) and t(11;17). Testing is recommended when FISH for t(15;17) is negative but extra RARA signals are seen to distinguish variant RARA translocations from trisomy 17. If indicated, follow-up metaphase FISH may be added to identify rearrangement partner chromosomes as an aid to therapy selection. Testing is also useful for verifying RARA status when morphology is suspicious for APL but t(15;17) FISH is negative.