SOX11
Use
Nuclear protein expression of SOX‑11 is highly associated with both cyclin D1‑positive and negative mantle cell lymphoma (MCL). SOX‑11 IHC is useful for identifying true cyclin D1‑negative MCL and further defining pathologic features of CD5+ DLBCL. Routine use of anti‑SOX‑11 in cases of suspected CD5+ DLBCL might help identify additional cases of cyclin D1‑negative blastoid MCL. SOX‑11 can also be detected in some BL, LBL, and T‑PLL, although the different morphological and phenotypic features of these malignancies allow easy recognition of the cases of cyclin D1‑negative MCL.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
A formalin‑fixed, paraffin‑embedded (FFPE) tissue block is preferred specimen type or one unbaked, unstained slide for H&E staining (required) and two to three (2‑3) positively charged unstained slides (all cut at 4‑5 microns) for each test/antibody ordered. Block and slide identifiers should be clearly written and match exactly with the specimen ID and specimen labeling as noted on the requisition.
Storage Instructions
Use cold pack for transport, making sure cold pack is not in direct contact with specimen.