Spirochete
Use
Immunohistochemical (IHC) localization of Treponema pallidum (spirochete) in formalin‑fixed paraffin‑embedded (FFPE) tissue enables accurate identification of the causative agent of syphilis. This method succeeds traditional silver stains (e.g., Steiner or Warthin‑Starry) by providing a more specific, reliable approach, though cross‑reactivity with Borrelia burgdorferi (Lyme disease) should be considered.
Special Instructions
Not provided.
Limitations
Cross‑reactivity of the anti‑spirochete antibody with Borrelia burgdorferi (Lyme disease) may lead to potential false‑positive staining. The test applies only to FFPE tissues and may not detect organisms in other specimen types.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
FFPE tissue block preferred or one unbaked unstained H&E slide and two to three positively charged unstained slides (4‑5 microns) per test.
Storage Instructions
Use cold pack for transport, not in direct contact with specimen; for NYS clients, provide date and time of collection.