Use

T‑cell leukemia/lymphoma protein 1 (TCL1) is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T‑cell leukemia and B‑cell lymphoma. TCL1 is expressed in more differentiated B‑cells, under both reactive and neoplastic conditions, from antigen committed B‑cells and in germinal center B‑cells; it is down‑regulated in the latest stage of B‑cell differentiation. The most useful application of TCL1 antibody is in the discrimination of B‑cell lymphomas from T‑cell lymphomas, CD30+ anaplastic large cell lymphomas, multiple myeloma, and marginal zone B‑cell lymphoma.