TCL1
Also known as: T Cell Leukemia/Lymphoma Protein 1
Use
T‑cell leukemia/lymphoma protein 1 (TCL1) is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T‑cell leukemia and B‑cell lymphoma. TCL1 is expressed in more differentiated B‑cells, under both reactive and neoplastic conditions, from antigen committed B‑cells and in germinal center B‑cells; it is down‑regulated in the latest stage of B‑cell differentiation. The most useful application of TCL1 antibody is in the discrimination of B‑cell lymphomas from T‑cell lymphomas, CD30+ anaplastic large cell lymphomas, multiple myeloma, and marginal zone B‑cell lymphoma.
Special Instructions
Not provided.
Limitations
Not provided.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
TCL1
Protein
Result Turnaround Time
24 hours
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
FFPE tissue block preferred; or one unbaked, unstained slide for H&E (required) plus two to three positively charged unstained slides (4‑5 microns) per test/antibody.
Causes for Rejection
Block and slide identifiers must match requisition.