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Early-onset high myopia is characterized by severe nearsightedness with a refractive error of at least -6.00 diopters that develops before age 10. This condition can present in isolation or as part of syndromes such as Stickler, Marfan, and SHORT syndrome. Non-syndromic myopia is influenced by genetic and environmental factors, with early-onset high myopia being more likely monogenic. The panel includes genes associated with non-syndromic myopia and primary ocular disorders. Inheritance patterns include X-linked, autosomal dominant, and recessive. The diagnostic yield varies with the clinical presentation and is expected to be about 20% based on a cohort study.