Use

This test detects genetic variants in the APOL1 gene—specifically the G1 (c.1024A>G & c.1152T>G) and G2 (c.1164_1169del) risk alleles—which increase susceptibility to certain forms of non-diabetic kidney disease. Individuals with two risk alleles (G1/G1, G1/G2, or G2/G2) are classified as having a “high‑risk genotype” and face a higher risk of progressive CKD, focal segmental glomerulosclerosis (FSGS), and end‑stage kidney disease compared with those with 0 or 1 risk allele (“low‑risk genotype”) ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq287?utm_source=openai)).

Not provided.