Apolipoprotein L1 (APOL1) Renal Risk Variant Genotyping
Also known as: APOL1: G1 and G2 allele, Apolipoprotein L1 Nephropathy, APOL1 Risk alleles, APO L1, APOL1 Genotyping
Use
This test detects genetic variants in the APOL1 gene—specifically the G1 (c.1024A>G & c.1152T>G) and G2 (c.1164_1169del) risk alleles—which increase susceptibility to certain forms of non-diabetic kidney disease. Individuals with two risk alleles (G1/G1, G1/G2, or G2/G2) are classified as having a “high‑risk genotype” and face a higher risk of progressive CKD, focal segmental glomerulosclerosis (FSGS), and end‑stage kidney disease compared with those with 0 or 1 risk allele (“low‑risk genotype”) ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq287?utm_source=openai)).
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Sanger
Biomarkers
APOL1
Gene
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Not provided.
Other tests from different labs that may be relevant