CAH Panel 6 (StAR Deficiency)
Also known as: Side chain cleavage deficiency
Use
Steroidogenic acute regulatory protein (StAR) catalyzes the initial rate‑limiting step in the formation of steroid hormones. Affected individuals present with deficiency of cortisol and aldosterone, as well as early precursors in the synthesis of steroid hormones (pregnenolone; DHEA). Additional testing may be required to establish a diagnosis.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
4 mL
Minimum Volume
1.6 mL
Container
Red‑top tube (no gel)
Collection Instructions
Collect blood in a Vacutainer® with no additives. Allow blood to clot (30 minutes) at room temperature (18‑25 °C). Centrifuge and separate the serum from the cells. Freeze as soon as possible. Specify age and sex on test request form. Immediately put sample on ice after collection.
Causes for Rejection
Moderate to gross hemolysis; Serum Separator Tube (SST®); Plasma
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 72 hours |
| Frozen | 14 days at –20 °C; 30 days at –70 °C |