Use

Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; low levels can lead to organ rejection following transplant. Peak concentrations are reached at approximately 3.5 hours after oral dosage, with elimination half‑life of 10–27 hours.