Cyclosporine A, Trough, LCMSMS, Blood
Use
Cyclosporine is a commonly used immunosuppressive drug in patients receiving transplants. LC/MS/MS methods have higher specificity for the parent compound than immunoassay. Therapeutic drug monitoring is useful to optimize dose and avoid toxicity. High cyclosporine levels can lead to nephrotoxicity; low levels can lead to organ rejection following transplant. Peak concentrations are reached at approximately 3.5 hours after oral dosage, with elimination half‑life of 10–27 hours.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
Cyclosporine
Analyte
LOINC Codes
- 53828-0 - cycloSPORINE Trough Bld-mCnc
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
2 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
Collect trough specimen approximately 1 hour before next dose
Causes for Rejection
Clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 6 days |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant