HLA B51 Behcet's Disease Association Test
Use
This test assesses the presence of the HLA‑B*51 allele, which is strongly associated with Behçet’s disease. HLA‑B*51:02 shows the strongest association, but detection is not diagnostic by itself and must be interpreted in clinical context. The test provides supportive evidence for Behçet’s disease, especially in patients presenting with recurrent mucocutaneous and ocular manifestations along the Silk Road distribution.
Special Instructions
Not provided.
Limitations
HLA‑B*51 positivity is associated with Behçet’s disease but is not diagnostic, as many individuals without the disease also carry the allele. Negative results do not rule out Behçet’s disease. Clinical correlation is essential.
Methodology
PCR-based (PCR)
Biomarkers
HLA‑B51
Protein
LOINC Codes
- 44726-8 - HLA-B51 Ql
Result Turnaround Time
8 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
5 mL (3 mL minimum) whole blood collected in an EDTA (lavender‑top) tube. If submitted with any other tests, submit separate tube for this test. Do not open tube or split sample.
Causes for Rejection
Clotted
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 7 days |
| Frozen | Unacceptable |
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