IGF‑1, LC/MS
Also known as: IGF1, Somatomedin-C, Insulin Like Growth Factor, IGF 1, Insulin-Like Growth Factor
Use
Measurement of Insulin‑like Growth Factor‑1 (IGF‑1) by liquid chromatography/mass spectrometry—a highly specific and accurate method—is utilized clinically to help assess growth hormone activity. IGF‑1 levels are useful in evaluating disorders of GH excess (e.g., acromegaly), GH deficiency (e.g., hypopituitarism), and nutritional status—levels decrease in undernutrition and normalize with improved nutrition. The assay is used in routine clinical evaluation of growth-related conditions.
Special Instructions
Performing laboratory: Quest Diagnostics Nichols Institute (San‑Juan Capistrano, CA). Setup schedule: Monday through Friday mornings (Mon‑Fri a.m.). Orderable via Quest Diagnostics referral; Quest test code “16293”.
Limitations
This test is a laboratory‑developed test; it has not been cleared or approved by the FDA. Analytical performance characteristics were validated under CLIA; assay is used for clinical purposes. Moderate hemolysis, gross lipemia, gross icterus, sample received in glass tube, or sample received at room temperature may compromise accuracy and lead to rejection.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 2484-4
- 73561-3
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Red‑top tube (no gel) or Serum Separator Tube (SST)
Collection Instructions
Collect blood in a red‑top tube (no gel) or SST. For red‑top tube, allow blood to clot 10‑15 minutes at room temperature. Separate serum from cells.
Storage Instructions
Transport refrigerated (cold packs); avoid room temperature.
Causes for Rejection
Moderate hemolysis; gross lipemia; received in glass tube; received at room temperature; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 7 days |
| Frozen | 60 days |