Image‑Guided Pap with Age‑Based Screening Protocols
Also known as: Age Based Pap Screening Protocol, Age Based Smart Codes Pap Screening, Smart Codes for Age Based Pap Screen, Cervical Cancer Screening Protocol, Age-Based
Use
This age‑based “Smart Code” test for cervical cancer screening integrates image‑guided Pap cytology with reflex testing for high‑risk HPV mRNA and screening for chlamydia and gonorrhea depending on age-defined criteria. It aligns with ACOG, USPSTF, and other guideline recommendations for women 21–65 to optimize detection of cervical precancer and associated infections using a combined screening approach. The test adapts screening components according to patient age and cytology outcomes, offering efficient, tailored, guideline‑based care.
Special Instructions
Smart Code simplifies ordering by combining multiple components—including image‑guided Pap (ThinPrep® or SurePath™), HPV mRNA reflex testing, and CT/NG testing where indicated—based on patient age and cytology results. The panels’ components can also be ordered separately if needed. Ordering follows ACOG age‑based guidelines; for more detail, individual components or test codes may vary by location.
Limitations
Performing Pap alone without associated reflex or infection testing may miss high‑risk HPV infections or coexisting sexually transmitted infections. Age-based logic depends on accurate age documentation and cytology result interpretation (e.g., ASC‑US). The reflex HPV and genotyping are contingent on Pap results and HPV positivity, respectively, which could delay full diagnostic information. Reflex tests incur additional charges and may involve non‑orderable reflex codes.
Methodology
Automated Analyzer
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Cervical Swab
Volume
Pap sample collected in 1 (1 minimum) ThinPrep® or SurePath™ pap vial
Minimum Volume
Not provided
Container
ThinPrep® or SurePath™ pap vial
Collection Instructions
Refer to Quest specimen collection and transport guide.
Causes for Rejection
SurePath™ vials without the head of the collection device(s) in the fluid; swabs; cervical swabs in Digene HC cervical sampler; Digene vials