Metanephrines, Fractionated, Free, LC/MS/MS, Plasma
Also known as: Metanephrines, Fractionated, LC-MS/MS, Plasma, Free Metanephrines
Use
Used for screening and diagnosis of catecholamine‑secreting tumors such as pheochromocytomas and paragangliomas. It quantifies free metanephrine and normetanephrine levels in plasma, which can aid in evaluating suspected adrenergic overproduction conditions.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
Metanephrine, Free
AnalyteNormetanephrine, Free
AnalyteTotal, Free (MN + NMN)
Analyte
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2.5 mL
Minimum Volume
1.5 mL
Container
EDTA (lavender‑top) tube, pre‑chilled
Collection Instructions
Draw specimen in a pre‑chilled EDTA lavender‑top Vacutainer. Keep whole blood on wet ice and centrifuge at ~4 °C within 2 hours, transfer plasma to plastic, leak‑proof vial and refrigerate.
Patient Preparation
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. Overnight fasting is preferred. Patients should be relaxed in either a supine or upright position before blood is drawn.
Causes for Rejection
Heparinized plasma, serum, CSF, urine
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 HOURS |
| Refrigerated | 14 DAYS |
| Frozen | 14 DAYS |
Other tests from different labs that may be relevant