Paraneoplastic Antibody Expanded Evaluation with Reflex to Titer and LB, Serum

Casandra

Casandra Test Code QD78889Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 94957CPT Codes 83520, 84182, 86256

Paraneoplastic Antibody Expanded Evaluation with Reflex to Titer and LB, Serum

Also known as: Autoimmune Paraneoplastic Panel Reflex, Paraneoplastic Autoimmune Evaluation, PNS Expanded, Para Expanded Serum

Clinical Use

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Use

This assay aids in the diagnosis of paraneoplastic syndromes and associated malignancies, autoimmune encephalopathies, and other autoimmune neurological diseases by detecting a panel of antineuronal autoantibodies via multiple methods including tissue immunofluorescence (IFA), cell-based assay (CBA), radioimmunoassay, and reflex to line blot (LB) with titers where appropriate ([intellitestmanager.questdiagnostics.com](https://intellitestmanager.questdiagnostics.com/home/output/218380?utm_source=openai)).

Special Instructions

Panel always performs CBAs for cell surface autoantibodies (e.g., NMDA, AMPAR, GABA‑B receptor, LGI1, CASPR2) regardless of IFA screening result to increase sensitivity ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq292?utm_source=openai)).