Thyroid Transcription Factor‑1 (TTF‑1), IHC, with Interpretation
Use
Thyroid transcription factor‑1 (TTF‑1) is a nuclear protein expressed in thyroid follicular cells, type II pneumocytes, and a subset of bronchial cells. Given its relative specificity for cells of thyroid or lung origin, this immunostain is often included in a panel to identify the primary site for carcinomas of unknown origin. Interpretation requires pathologist review to provide full diagnostic evaluation. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/70576?utm_source=openai))
Special Instructions
Not provided.
Limitations
This test includes only technical performance of the IHC stain; interpretation is not included and must be ordered separately (e.g., PATHC / Pathology Consultation). Age of cut paraffin sections may affect immunoreactivity; best practice is to use sections cut within six weeks. ([mayocliniclabs.com](https://www.mayocliniclabs.com/test-catalog/overview/70576?utm_source=openai))
Methodology
Immunoassay (IHC)
Biomarkers
TTF‑1
Protein
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Sections should be on Plus‑charged slides; submit H&E slide if interpretation requested.
Storage Instructions
Room temperature; use cold packs for transport of blocks during summer months.
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