17-Hydroxyprogesterone Quantitative by HPLC-MS/MS, Serum or Plasma

Casandra

Casandra Test Code AR22361Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0092332CPT Code 83498

17-Hydroxyprogesterone Quantitative by HPLC-MS/MS, Serum or Plasma

Also known as: OHPRGSTON

Clinical Use

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Use

The 17-Hydroxyprogesterone Quantitative by HPLC-MS/MS test is clinically significant for evaluating 21-Hydroxylase Deficiency, a common cause of Congenital Adrenal Hyperplasia (21-OHD CAH). It also plays a crucial role in diagnosing Polycystic Ovary Syndrome (PCOS) and adrenal insufficiency. This test assists in the diagnosis and management of these conditions by measuring the levels of 17-Hydroxyprogesterone, a steroid hormone produced during the synthesis of cortisol. Variations in 17-Hydroxyprogesterone levels may indicate a hormonal imbalance or enzyme deficiency impacting adrenal steroidogenesis.

Special Instructions

This test is New York state approved, indicating the approval for use within New York due to compliance with state laboratory regulations. It's important to ensure correct specimen type and temperature during collection and transportation to maintain the integrity of the specimen and the accuracy of the test results.

Limitations

The test may be affected by hemolyzed specimens, which are considered unacceptable conditions for testing. It is crucial to follow the specimen preparation instructions meticulously to avoid interference from other substances or poor specimen quality that could lead to inaccurate results. Furthermore, while the test provides quantitative data on 17-Hydroxyprogesterone levels, it does not specify the exact cause of hormonal imbalances or enzyme deficiencies, necessitating further testing for differential diagnosis.

Test Details

New York Approved