17-OH Progesterone/Creatinine Ratio, Random Urine

Casandra

Casandra Test Code LC15198Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 070340CPT Codes 82570, 83498

17-OH Progesterone/Creatinine Ratio, Random Urine

Also known as: 17-OHP Urine

Clinical Use

Order Test

Use

17-Hydroxyprogesterone (17-OHP) in urine is greatly elevated in patients with polycystic ovarian disease and in patients with idiopathic hirsutism. Wong and coworkers showed that measurement of 17-OHP in 24-hour urine produced results that may be useful for monitoring glucocorticoid and mineralocorticoid therapy in patients with congenital adrenal hyperplasia (CAH).1 Other studies have shown that 17-OHP in 24-hour urine correlated well with serum 17-OHP and suggested that the urine measurement of 17-OHP may be a reliable alternative to serum 17-OHP measurement for monitoring of CAH therapy.2,3

Special Instructions

Random urine collection is required. If the original container is received with pH >3 but <5, adjust the pH to <3 using 6N HCl to ensure accurate test results.

Limitations

This test has been developed and its performance characteristics determined by Labcorp. However, it has not been cleared or approved by the Food and Drug Administration, which limits its use to settings that understand and accommodate for the lack of such clearance or approval. The validity of the test is supported by published research, but users should be cautious about interpretative constraints in broader clinical contexts.

Test Details

Methodology

Mass Spectrometry

Biomarkers

LOINC Codes

Order Codes

1670-9
2161-8
63042-6

Result Codes

1670-9
2161-8
63042-6

Result Turnaround Time

4-6 days

Specimen

Urine

Volume

30 mL aliquot

Minimum Volume

4 mL aliquot

Container

Random urine transport tube containing 6N HCl or urine Monovette® with pH stabilizer

Collection Instructions

Ensure to add preservative to the container prior to collection. Use plastic urine container if collecting without Monovette®, adjusting pH to <5 with 6N HCl.