β2-Glycoprotein 1 Antibodies, IgG, IgM
Also known as: Anti-β2 Glycoprotein 1, Beta-2 Glycoprotein 1 Antibodies
Use
Assess the risk of thrombosis in patients who may be at risk for antiphospholipid syndrome (APS). This test should be used in conjunction with current traditional anticardiolipin and anticoagulant tests.1
Special Instructions
Recently, an international consensus group of experts in the diagnosis and management of antiphospholipid syndrome concluded that β2-Glycoprotein 1 IgG and IgM antibodies should be included as diagnostic criteria for APS. The test includes semiquantitative results for IgG and IgM antibodies against β2-glycoproteins.
Limitations
Anti-β2-glycoprotein 1 should not be used alone as a screening test for antiphospholipid syndrome. Testing positive for β2-GP1 antibodies can occur in approximately 20% of patients who test negative for anticardiolipin antibodies (ACA). This test is useful in patients with positive ACA results and a clinical picture inconsistent with APS. However, a negative anti-β2-GP1 result does not exclude APS if clinical suspicion is strong.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 72488-0
- 16135-6
- 16136-4
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 15 days |
| Refrigerated | 15 days |
| Frozen | 15 days |
Other tests from different labs that may be relevant