21-Deoxycortisol, LC/MS (Endocrine Sciences)
Use
21-Deoxycortisol is a marker for the 21-hydroxylase deficiency (congenital adrenal hyperplasia [CAH]). The steroid is less than 10 in 98% of subjects without known CYP21A2 gene deficiency. 21-Deoxycortisol has been reported to be elevated in late-onset CAH.1 21-Deoxycortisol has been reported 2 to be elevated after ACTH stimulation in samples from patients that are heterozygous for CYP21A2 gene mutations and from patients with nonclassical CAH.
Special Instructions
Serum or plasma must be separated from cells within two hours of venipuncture. Submit serum or plasma in a plastic transport tube. The sample is stable frozen for 14 days and exhibits stability at room temperature or refrigerated for the same duration. Freeze/thaw cycles are stable up to three times.
Limitations
The test has not been cleared or approved by the FDA. It may require additional time for confirmatory or reflex tests. The usual turnaround time is 8 to 10 days from specimen pickup to result release, but schedules may vary. Testing is developed and performed by LabCorp with specific performance characteristics.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 74872-3
Result Turnaround Time
8-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
plastic transport tube
Collection Instructions
Separate serum or plasma from cells within two hours of venipuncture.
Storage Instructions
Freeze. Stable frozen for 14 days. Stable at room temperature or refrigerated for 14 days. Freeze/thaw cycles stable x3.
Causes for Rejection
Gross hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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