Alpha-1-Antitrypsin Phenotype (Includes Alpha-1-Antitrypsin)
Also known as: A1A PHENO
Use
The Alpha-1-Antitrypsin Phenotype test is used to determine the specific AAT protein variant(s) in individuals with decreased concentration of AAT, specifically those with an AAT level of less than 90mg/dL. It helps identify the presence of deficiency variants like the Z allele, which can affect lung elasticity and are clinically significant in smokers, who may experience increased rates of lung function decline.
Special Instructions
Interpretation of the results should be made with caution if the patient has been transfused within the previous 21 days, as this can potentially alter phenotype outcomes and confound the results.
Limitations
The test results may be impacted by recent transfusions within 21 days prior to testing, potentially confounding phenotype determination. Additionally, while the presence of deficiency alleles such as the Z allele is identified, the test does not provide a quantitative assessment of the associated clinical risk for lung disease or other potential manifestations associated with AAT deficiency.
New York Approved
Methodology
Immunoassay (Immunoturbidimetry)
Biomarkers
LOINC Codes
- 1825-9
- 32769-2
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect using Serum Separator Tube (SST) or Plain Red.
Storage Instructions
Refrigerated.
Causes for Rejection
Grossly hemolyzed specimens. Avoid repeated freeze/thaw cycles.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 3 months |
| Frozen | 3 months |
Other tests from different labs that may be relevant