Anti-N-methyl-D-Aspartate Receptor (NMDAR), Spinal Fluid

Casandra

Casandra Test Code LC56496Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 505720CPT Code 86255

Anti-N-methyl-D-Aspartate Receptor (NMDAR), Spinal Fluid

Also known as: Autoimmune Dementia Panel Spinal Fluid, Paraneoplastic

Clinical Use

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Use

NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.

Special Instructions

If reflex test is performed, additional charges/CPT code(s) may apply.

Limitations

This test was developed and validated by Labcorp in compliance with CLIA requirements but has not been cleared or approved by the FDA. This should be considered when interpreting results, and additional confirmatory tests should be considered as necessary.

Test Details