Anticardiolipin Antibodies (ACA), IgG, IgM, Quantitative
Also known as: Antiphospholipids, Cardiolipin Antibodies
Use
Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome.1,2
Special Instructions
The presence of ACA should be confirmed with repeated positive results at least six weeks apart to distinguish between transient antibodies and those significant for APS. Due to the heterogeneity of antibodies associated with APS, both lupus anticoagulant (LA) and ACA testing are recommended when APS is suspected.
Limitations
ACA can be transiently observed in the general population, particularly during the convalescent phase of infections, such as bacterial and viral infections, as well as in individuals with syphilis. These transient antibodies are typically not associated with an increased risk of clinical complications. As many of these antibodies are not linked to APS, a single ACA result is insufficient for diagnosis. The diagnostic accuracy for APS is enhanced by considering both LA and ACA results, as LA tests are generally more specific for APS despite ACA's higher sensitivity.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 3180-7
- 3181-5
- 3182-3
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; icteric specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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