Celiac Disease Comprehensive Panel
Use
This panel detects the presence of celiac-associated antibodies, specifically transglutaminase‑IgA (tTG‑IgA) and total Immunoglobulin A (IgA), in blood. Since approximately 2–3% of celiac disease patients are IgA deficient, measuring total IgA helps ensure accurate interpretation of tTG‑IgA results, reducing false‑negatives. Gluten must be included in the patient’s diet at the time of testing to ensure validity. Abnormal results should be interpreted by a clinician to determine further diagnostic steps.
Special Instructions
Requires blood sample collection, typically at a Quest Diagnostics Patient Service Center or via Quest Mobile®. No doctor’s visit necessary for consumer‑initiated orders (QuestHealth). Gluten exposure in diet prior to testing is required. Purchasing and sample collection logistics are managed via QuestHealth platform with physician oversight.
Limitations
Does not itself provide a definitive diagnosis of celiac disease—abnormal results require clinical correlation and possibly further testing. IgA deficiency may affect tTG‑IgA interpretation. Accuracy relies on adequate gluten ingestion at time of testing. Consumer‑initiated testing follows specific eligibility requirements (e.g., age limits, location restrictions) and may include additional physician service fees.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided
Collection Instructions
Blood draw—venous specimen collected at a Quest Diagnostics Patient Service Center or via Quest Mobile®
Patient Preparation
Diet must include gluten prior to testing
Other tests from different labs that may be relevant