CLL FISH Profile
Also known as: Vysis CLL FISH Probe Kit
Use
This test is a diagnostic test for chronic lymphocytic leukemia (CLL). It has an improved detection rate compared to a chromosome study, increasing from 45% to 80% when using fluorescence in situ hybridization (FISH). It also aids in differentiating CLL from mantle cell lymphoma (MCL).
Special Instructions
Indicate pertinent clinical diagnosis and previous cytogenetic studies on the request form.
Limitations
Molecular mutations or chromosomal alterations not targeted by the probes included in this profile will not be detected by the test. This limitation means that some disease-related changes may not be identified.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal)
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible. Adjust tube size to sample volume to avoid heparin toxicity.
Storage Instructions
Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis
Other tests from different labs that may be relevant