Use

Infection by Coccidioides immitis can produce a spectrum of disease with most patients being asymptomatic and some developing disseminated disease including pneumonia and meningitis. C. immitis meningitis is associated with a mononuclear pleocytosis. Antibody in CSF is considered diagnostic for coccidioidal meningitis, although some patients (~10%) may not have detectable antibody in CSF. False-negatives may occur in patients with solitary pulmonary lesions and cross‑reactions may occur in patients with active histoplasmosis. Elevated serum antibodies may be present in meningeal coccidioidomycosis.